AustralieFrV1, Main, Exploration, bibRecord, 008F14

A phase III randomized comparison of lapatinib plus capecitabine versus capecitabine alone in women with advanced breast cancer that has progressed on trastuzumab : updated efficacy and biomarker analyses

Identifieur interne : 008F14 ( Main/Exploration ); précédent : 008F13; suivant : 008F15

A phase III randomized comparison of lapatinib plus capecitabine versus capecitabine alone in women with advanced breast cancer that has progressed on trastuzumab : updated efficacy and biomarker analyses

Auteurs : David Cameron [Royaume-Uni] ; Michelle Casey [États-Unis] ; Michael Press [États-Unis] ; Deborah Lindquist [États-Unis] ; Tadeusz Pienkowski [Pologne] ; C. Gilles Romieu [France] ; Stephen Chan [Royaume-Uni] ; Agnieszka Jagiello-Gruszfeld [Pologne] ; Bella Kaufman [Israël] ; John Crown [Irlande (pays)] ; Arlene Chan [Australie] ; Mario Campone [France] ; Patrice Viens [France] ; Neville Davidson [Royaume-Uni] ; Veira Gorbounova [Russie] ; Johannes Isaac Raats [Afrique du Sud] ; Dimosthenis Skarlos [Grèce] ; Beth Newstat [États-Unis] ; Debasish Roychowdhury [États-Unis] ; Paolo Paoletti [États-Unis] ; Cristina Oliva [États-Unis] ; Stephen Rubin [États-Unis] ; Steven Stein [États-Unis] ; Charles E. Geyer [États-Unis]

Source :

Breast cancer research and treatment [ 0167-6806 ] ; 2008.

RBID : Pascal:09-0067549

Descripteurs français

Pascal (Inist)
- Randomisation, Etude comparative, Lapatinib, Capécitabine, Association médicamenteuse, Adulte, Femme, Stade avancé, Cancer du sein, Trastuzumab, Efficacité traitement, Marqueur biologique, Métastase, Inhibiteur de la tyrosine kinase, Protooncogène, Gène erbB2, Anticancéreux, Promédicament.
Wicri :
- topic : Adulte, Femme.

English descriptors

KwdEn :
- Adult, Advanced stage, Antineoplastic agent, Biological marker, Breast cancer, Capecitabine, Comparative study, Drug combination, Lapatinib, Metastasis, Prodrug, Protooncogene, Randomization, Trastuzumab, Treatment efficiency, Tyrosine kinase inhibitor, Woman, erbB2 Gene.

Abstract

Purpose Lapatinib is a small molecule, dual tyrosine kinase inhibitor of epidermal growth factor receptor (EGFR) and human epidermal growth factor receptor type 2 (HER2). Initial results of a phase III trial demonstrated that lapatinib plus capecitabine is superior to capecitabine alone in women with HER2-positive advanced breast cancer that progressed following prior therapy including trastuzumab. Updated efficacy and initial biomarker results from this trial are reported. Results 399 women were randomized. The addition of lapatinib prolonged TTP with a hazard ratio (HR) of 0.57 (95% CI, 0.43-0.77; P < 0.001) and provided a trend toward improved overall survival (HR: 0.78, 95% CI: 0.55-1.12, P = 0.177), and fewer cases with CNS involvement at first progression (4 vs. 13, P = 0.045). Baseline serum HER2 ECD did not predict for benefit from lapatinib. Conclusion The addition of lapatinib to capecitabine provides superior efficacy for women with HER2-positive, advanced breast cancer progressing after treatment with anthracycline-, taxane-, and trastuzumab-based therapy. Biomarker studies could not identify a subgroup of patients who failed to benefit from the addition of lapatinib to capecitabine.

Affiliations:

Links toward previous steps (curation, corpus...)

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Le document en format XML

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<author><name sortKey="Gorbounova, Veira" sort="Gorbounova, Veira" uniqKey="Gorbounova V" first="Veira" last="Gorbounova">Veira Gorbounova</name>
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<author><name sortKey="Raats, Johannes Isaac" sort="Raats, Johannes Isaac" uniqKey="Raats J" first="Johannes Isaac" last="Raats">Johannes Isaac Raats</name>
<affiliation wicri:level="1"><inist:fA14 i1="16"><s1>Panorama Medical Center</s1>
<s2>Cape Town</s2>
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<author><name sortKey="Skarlos, Dimosthenis" sort="Skarlos, Dimosthenis" uniqKey="Skarlos D" first="Dimosthenis" last="Skarlos">Dimosthenis Skarlos</name>
<affiliation wicri:level="3"><inist:fA14 i1="17"><s1>2nd Medical Oncology Department of Errikos Dunan Hospital, Errikos Dynan Hospital-B</s1>
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<placeName><settlement type="city">Los Angeles</settlement>
<region type="state">Californie</region>
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<orgName type="university">Université de Californie du Sud</orgName>
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<country>États-Unis</country>
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<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>GlaxoSmithKline</s1>
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<s3>USA</s3>
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<s3>USA</s3>
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<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>GlaxoSmithKline</s1>
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<s3>USA</s3>
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<sZ>20 aut.</sZ>
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<author><name sortKey="Geyer, Charles E" sort="Geyer, Charles E" uniqKey="Geyer C" first="Charles E." last="Geyer">Charles E. Geyer</name>
<affiliation wicri:level="1"><inist:fA14 i1="18"><s1>Department of Human Oncology, Allegheny General Hospital</s1>
<s2>Pittsburgh, PA</s2>
<s3>USA</s3>
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<country>États-Unis</country>
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<series><title level="j" type="main">Breast cancer research and treatment</title>
<title level="j" type="abbreviated">Breast cancer res. treat.</title>
<idno type="ISSN">0167-6806</idno>
<imprint><date when="2008">2008</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
<seriesStmt><title level="j" type="main">Breast cancer research and treatment</title>
<title level="j" type="abbreviated">Breast cancer res. treat.</title>
<idno type="ISSN">0167-6806</idno>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term>
<term>Advanced stage</term>
<term>Antineoplastic agent</term>
<term>Biological marker</term>
<term>Breast cancer</term>
<term>Capecitabine</term>
<term>Comparative study</term>
<term>Drug combination</term>
<term>Lapatinib</term>
<term>Metastasis</term>
<term>Prodrug</term>
<term>Protooncogene</term>
<term>Randomization</term>
<term>Trastuzumab</term>
<term>Treatment efficiency</term>
<term>Tyrosine kinase inhibitor</term>
<term>Woman</term>
<term>erbB2 Gene</term>
</keywords>
<keywords scheme="Pascal" xml:lang="fr"><term>Randomisation</term>
<term>Etude comparative</term>
<term>Lapatinib</term>
<term>Capécitabine</term>
<term>Association médicamenteuse</term>
<term>Adulte</term>
<term>Femme</term>
<term>Stade avancé</term>
<term>Cancer du sein</term>
<term>Trastuzumab</term>
<term>Efficacité traitement</term>
<term>Marqueur biologique</term>
<term>Métastase</term>
<term>Inhibiteur de la tyrosine kinase</term>
<term>Protooncogène</term>
<term>Gène erbB2</term>
<term>Anticancéreux</term>
<term>Promédicament</term>
</keywords>
<keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Adulte</term>
<term>Femme</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Purpose Lapatinib is a small molecule, dual tyrosine kinase inhibitor of epidermal growth factor receptor (EGFR) and human epidermal growth factor receptor type 2 (HER2). Initial results of a phase III trial demonstrated that lapatinib plus capecitabine is superior to capecitabine alone in women with HER2-positive advanced breast cancer that progressed following prior therapy including trastuzumab. Updated efficacy and initial biomarker results from this trial are reported. Results 399 women were randomized. The addition of lapatinib prolonged TTP with a hazard ratio (HR) of 0.57 (95% CI, 0.43-0.77; P < 0.001) and provided a trend toward improved overall survival (HR: 0.78, 95% CI: 0.55-1.12, P = 0.177), and fewer cases with CNS involvement at first progression (4 vs. 13, P = 0.045). Baseline serum HER2 ECD did not predict for benefit from lapatinib. Conclusion The addition of lapatinib to capecitabine provides superior efficacy for women with HER2-positive, advanced breast cancer progressing after treatment with anthracycline-, taxane-, and trastuzumab-based therapy. Biomarker studies could not identify a subgroup of patients who failed to benefit from the addition of lapatinib to capecitabine.</div>
</front>
</TEI>
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<li>Los Angeles</li>
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<country name="France"><region name="Occitanie (région administrative)"><name sortKey="Gilles Romieu, C" sort="Gilles Romieu, C" uniqKey="Gilles Romieu C" first="C." last="Gilles Romieu">C. Gilles Romieu</name>
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A phase III randomized comparison of lapatinib plus capecitabine versus capecitabine alone in women with advanced breast cancer that has progressed on trastuzumab : updated efficacy and biomarker analyses

A phase III randomized comparison of lapatinib plus capecitabine versus capecitabine alone in women with advanced breast cancer that has progressed on trastuzumab : updated efficacy and biomarker analyses

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